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The loss extends Chicago’s losing skid to a season-long eight games.
The hit by Martinez was the first for Houston since the first inning, but Justin Maxwell and Carlos Lee both drew two-out walks before it to set up the score.
Alfonso Soriano led off the fourth inning with a solo shot to left-center field that tied it at 1-1. The home run marked the first time in four games that Chicago had scored before the ninth inning.